In situ Sensors:
- Particle size and count (FBRM G400 MT)
- FT-IR (ReactIR 15 MT)
- UV-vis (UV-Vis Cary50)
- Heat Flow Calorimetry (EasyMax102 HFCal)
- Temperature, Turbidity and pH
Controlled Reactors:
- Mettler-Toledo EasyMax (50 mL÷100 mL)
- Atlas Jacketed Reactor (50ml÷5L)
- Pressure Reactor (up to 5L)
Filtering and Drying:
- Vacuum filtration
- Agitated filter drier (up to 2L)
- Centrifuge
- Buchi B-290 Spray Dryer
Kilo-lab scale non-GMP (50L):
- Multi-purpose Kilolab units ideal to run experiments at kilo scale during development.
Structural Characterization:
- XRPD (PANalytical X'Pert3 Powder)
- XRPD (RIGAKU Miniflex 600)
- XRPD Single Crystal (SC-XRPD)
- Variable Temperature XRPD (VT-XRPD)
- FT-IR/FT-RAMAN (Thermo Nicolet iS50)
- Form Determination/Quantification
- Inductively Coupled Plasma MS (ICP-MS)
- Scanning Electron Microscopy (SEM)
- Solid State NMR (Bruker AVANCE II 400)
- PLM (Motic Microscope BA210)
- BET Surface Area(Micromeritics TriStar II)
Physicochemical Properties:
- PARTICLE SIZE AND SHAPE (Malvern Morphologi G3)
- PSD (Malvern Mastersizer 3000)
- Liquid State NRM (NMR)
- DISSOLUTION (Agilent 708-DS)
- SOLUBILITY (Avantium Crystal16)
- CHEMICAL IDENTITY (Agilent ACQUITY)
- CHEMICAL PURITY (HPLC UV, DAD, ED, RI, FL)
- WATER CONTENT (Mettler-Toledo Karl-Fischer)
- DYNAMIC VAPOUR SORPTION (DVS SMS Intrinsic)
Thermal Analysis:
- DSC (Mettler-Toledo DSC)
- TGA-EGA (Mettler-Toledo TGA coupled Thermo Nicolet iS 10IR)
- TGA (Mettler-Toledo TGA)
- GC (Agilent 7820A)
- Hot-Stage Microscopy (HSM)
Rheological Properties:
- Viscosity / Disco-Elasticity
- Flowability / Aeration
- Shear Cell / Wall Friction
- Compressibility / Permeability
- Bulk / Tapped Density
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