CrystalForms@Bologna 2021 - online meeting – Final Programme Friday 10 September

9:30-9:40

Opening of the Event, Dario Braga, MCE lab, Department of Chemistry, University of Bologna

9:40-10:00

Solubility and Permeability Issues in Drug Solid Forms, Gautam R. Desiraju, Indian Institute of Science, India

10:00-10:20

The Search for Polymorphs of a Prolific Solvate Former, Galunisertib, Susan Reutzel-Edens, Cambridge Crystallographic Data Centre, UK

10:20-10:40

Comparing nucleation and growth rates of molecular crystals, Roger Davey, University of Manchester, UK

10:40-11:20

Discussion and coffee

11:20-11:40

Structural analysis of metastable pharmaceutical loratadine form II, by 3D electron diffraction and DFT+D energy minimisation, Grahame R Woollam, Scientific Lead, Associate Director Data Science, MatSci Scientific Modelling, Novartis Pharma AG and Partha Pratim Das, Application Specialist, NanoMEGAS SPRL

11:40-12:00

On the entropy cost of solvates, Alessia Bacchi, Dipartimento SCVSA - University of Parma, Italy

12:00-12:20

Living with the Risk for Crystallisation in the case of Amorphous Formulations, Luc Aerts, UCB Pharma, Belgium

12:20-12:40

Polymorphism and selectivity in inclusion compounds, Susan Bourne, University of Cape Town, South Africa

12:40-13:00

Discussion

13:00-14:00

Lunch break & flash presentations

14:00-14:20

Investigation of nanocrystalline and amorphous organic compounds using pair-distribution functions, Martin Schmidt, Goethe University Frankfurt Institute of Inorganic and Analytical Chemistry, Germany

14:20-14:40

NMR tools for the characterization of pharmaceutical crystal forms, Michele Chierotti, Department of Chemistry, University of Torino, Italy

14:40-15:00

Elusive predicted polymorphs - industrially relevant or not?, Philipp Ectors, Solid State Sciences - Particle Design, Pharma Technical Development Synthetic Molecules, F. Hoffmann-La Roche Ltd, Switzerland

15:00-15:20

The thin line between polymorphism and solid-solutions, Aurora Cruz Cabeza, University of Manchester, UK

15:20-16:00

Discussion & coffee

16:00-16:20

Tackling antimicrobial and anti enzymatic activity via cocrystallization, Fabrizia Grepioni, Department of Chemistry, University of Bologna, Italy

16:20-16:40

Crystal Engineering applied to enantiomeric resolution of racemic Fluoxetine, Javier Alcides Ellena, Sao Carlos Institute of Physics, University of Sao Paulo, Sao Carlos, SP - Brazil

16:40-17:00

Mechanisms of Powder Caking from the Solid State Perspective, Ana Kwokal, SYNGENTA, UK

17:00-17:20

Mechanochemical and Tribochemical Synthesis of Pharmaceutical Molecules and Solid Forms, Tomislav Frišcic, McGill University, Canada

17:20-18:00

Discussion & drink

18:00-19:20

Gold Sponsors session:

 

CRYSTAL GROWTH and DESIGN, Jon Steed, Editor in Chief

THERMO FISHER SCIENTIFIC Inc: (NYSE: TMO), Polymorphic Characterization of compounds using XRD and Raman Spectroscopy, Raphael Yerly, Product Manager XRD & Bruno Beccard, European Product Specialist Raman, Microscopy & Hi End Infrared

SPINOFRIN, Spray Flash Evaporation: An efficient process to engineer submicron Active Pharmaceutical Ingredients by Pierre Le Blainvaux, Jean-Baptiste Coty, Ilaria Ferrando, Ce´dric Martin, Isabella Telo`, Denis Spitzer , Speaker: Denis Spitzer

NETZSCH Geraetebau GmbH : Thermal Analysis for Polymorphism and Thermal Degradation Studies, Ekkehard Fuglein, Dr: rer: nat: Dipl:-Chem:, Senior Scientist

ELDICO Scientific AG: Overcoming the crystallization bottleneck: a dedicated electron diffractometer for the structure determination of nanocrystalline products, Arianna Lanza, ELDICO Scientific AG, Park Innovare: delivery LAB, 5234 Villigen, Switzerland

19:20-20:00

Flash presentations & aperitif

Saturday 11 September

9:00-9:20

Crystal Engineering of Solid-state Pharmaceuticals: From Synthons to Salt-Cocrystal Drugs, Ashwini K. Nangia, School of Chemistry, University of Hyderabad, India

9:20-9:40

News about the solid form landscapes of co-formers, Doris Braun, University of Innsbruck, Institute of Pharmacy, Austria

9:40-10:00

Cocrystals then and now, Mike Zaworotko, Bernal Institute, University of Limerick, Ireland

10:00-10:20

Cocrystal, ionic cocrystal and corresponding salts, Nicholas Blagden, University of Lincoln, UK

10:20-11:00

Discussion & coffee

11:00-11:20

The commercialisation conundrum, when a molecule has a hydrated solid form, Pat Basford, Senior Principal Scientist, Pfizer R & D, UK Ltd

11:20-11:40

Mechanochemical reactivity inhibited, prohibited and reversed by liquid additives, Bucar Kreso, Department of Chemistry at University College London in London, UK

11:40-12:00

APIs' polymorphism and other issues, Enrico Modena, PolyCrystalLine s.p.a., Italy

12:00-12:20

A tautomer in my tablet! Occurrence and implications, Amy Woods-Ryan, The University of Manchester and GSK, UK

12:20-13:00

Discussion

13:00-14:00

Lunch break

14:00-14:20

Why don’t we find more polymorphs?, Sarah (Sally) L. Price FRS, University College London, UK

14:20-14:40

Not just polymorphism: The particle size as API CQA for drug product development, Matteo Daldosso, Aptuit, an Evotec Company, Italy

14:40-15:00

Polymorphism of Sugars and the Use of Optical Rotation for the Detection of Crystalline Forms, Martin Viertelhaus, BASF SE, Advanced Materials & Systems Research, Germany

15:00-15:20

Expanding the life of old antibiotics: Multicomponent crystal forms and antibiotic coordination frameworks Vania André, Istituto Superior Technico, Lisbon, Portugal

15:20-16:00

Discussion & coffee

16:00-16:20

Extraordinary Mechanical Properties of Organic Crystals and Implications for Solid Dosage Formulations, Pance Naumov, New York University / New York University Abu Dhabi, USA

16:20-16:40

Preferential cocrystallization for the resolution of drug compounds, Tom Leyssens, UCLouvain, Belgium

16:40-17:00

Unraveling complexity in the development of a hydrate form: a scientific journey from molecule to crystal to medicine, Alessandra Mattei, Principal Research Scientist, AbbVie Inc, USA

17:00-17:20

Using Advanced Crystallization Methods to Fill in the Solid Forms Landscape, Jonathan Steed, Durham University, UK

17:20-17:40

Tackling antimicrobial and anti enzymatic activity via cocrystallization, Fabrizia Grepioni, Department of Chemistry, University of Bologna, Italy

17:40-19:00

Discussion, poster and videoclip prizes announcement and closing remarks



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