PolyCrystalline provides reliable solutions to optimise and control the crystallisation process of Active Pharmaceutical Ingredients for pharmaceutical companies, since 2005.

Our mission is to support our clients during drug development, helping them to reduce batch failure, avoiding costly crystallisation issues and overall offering greater confidence in drug quality during manufacturing. We can support you from early-phase drug discovery to kilogram supply.


We are a high performing cohesive team of trained chemists and analysts, with more than 10 years of experience in the development and optimization of APIs crystallization. We care about results and innovation based on sound science and the use of modern technologies.







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  FDA inspected test facility for the analysis of pharmaceutical products.                                      Our analytical department is certified to work according to GMP by AIFA. The GMP certification includes: X-ray powder diffraction analysis (quantitative/qualitative) FT-Raman (quantitative/qualitative) FT-IR (quantitative/qualitative) PSD   PolyCrystalLine receiv

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Equipment & Capabilities

In situ Sensors: Particle size and count (FBRM G400 MT) FT-IR (ReactIR 15 MT) UV-vis (UV-Vis Cary50) Heat Flow Calorimetry (EasyMax102 HFCal) Temperature, Turbidity and pH Controlled Reactors: Mettler-Toledo EasyMax (50 mL÷100 mL) Atlas Jacketed Reactor (50ml÷5L) Pressure Reactor (up to 5L) Filtering and Drying: Vacuum filtration Agitated filter drier (up to 2L) Centrifuge Buchi B-290 Spray Dryer Kilo-lab scale non-GMP (50L): Multi-purpose Kilolab units ideal to run exper

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Our History

WHERE we started: We began as a start-up business from the University of Bologna, the capital and largest city of the Emilia-Romagna Region in Northern Italy. WHEN we started: In 2005 PolyCrystalLine was self-founded by a group of young scientistsfrom the Molecular Crystal Engineering Group of UNIBO.   WHY we started: This was is response to the increasing interest from the pharmaceutical industry of a hi-tech partner specialized in solid-state chemistry able to design and control the properties of API an

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