Solid Form Screening & Selection

Solvates/Hydrates Identification

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mercoledì 22 aprile 2015

In amorphous and crystalline forms, a solid drug may be anhydrous or a solvate/hydrate. When a solid form contains a solvent, it is known as a solvate. The presence of residual solvent may affect dramatically the crystalline structure of the solid depending on the type of intermolecular forces that the solvent may have with crystalline solid. When the solvent is water, it is termed a hydrate.

Due to the frequent presence of water in the environment and its use in solvent blendings during the crystallization process, the formation of hydrated drugs is common. Because the water molecule is small and able to form hydrogen bonds, it is easily incorporated into the crystalline lattice of drugs both occupying spaces and stabilizing the structure.

How can we help you?

  • Explore the formation of hydrates, which usually show a wide range of properties that can be very different from the parent, anhydrous material
  • Determine the formation of hydrates can affects the product solubility and stability at various conditions

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