DETERMINE: Analytical services

Physical characterization

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martedì 5 gennaio 2016

Understanding the physicochemical properties of a compound is essential so that the formulation process can be rational and streamlined. The size and shape of a statistically relevant number of individual particles can be investigated, significantly improving process understanding (i.e. morphology affects the ease with which a pharmaceutical formulation can be pressed into a tablet).


Particle Size Distribution (PSD)

     

Determines information about the size and range of a set of particles representative of a material.

Rheological Properties

 

Flowability, aeration, shear cell, compressibility, permeability, viscosity, viscoelasticity, creep, yield stress, and linear viscoelastic region.

Bulk Density

 

Is the ratio of the mass of an untapped powder sample and its volume including the contribution of the interparticulate void volume.

Tapped Density

 

It is determined after defined compaction of the powder. The tap volume and the tap density include pores and interparticle spaces yet not of the loose bulk powder but of the compacted sample.

Solubility

 

The solubility properties of an API are part of the fundamental physicochemical properties determined in preformulation studies.

Dissolution Rate

 

Provides critical drug release information for drug development and quality control purposes.

pKa determination

 

pKa is a measure of the strength of the interaction of a compound with a proton. The lower the pKa of a drug, the more acidic it is.

LogP determination

 

Is the logarithm of the relative concentration of the molecule dissolved in an organic medium versus that dissolved in water.

LogD determination

 

Is the same as LogP except, unlike the latter, it also includes the ionic species.

Melting Point (MP)

 

Provides a first impression of the purity of a substance.

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