DISCOVERY: Solid form screening

Salts & Co-crystals screening

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mercoledì 22 aprile 2015

Co-crystals are drug solids defined as multicomponent molecular crystals in which at least one of the compounds is an active pharmaceutical ingredient (API). Salts are considered different from co-crystals provided that they are crystals formed by ionic multicomponent.

Salt formation is one of the primary solid-state approaches used to modify the physical properties of APIs. However, a major limitation within this approach is that the API must possess a suitable (basic or acidic) ionisable site. In comparison, co-crystals offer a different pathway, where any API regardless of acidic, basic or ionisable groups, could potentially be co-crystallized.

How can we help you?

  • Investigate the formation of co-crystals and salts when the API itself is not sufficiently soluble or stable, or is difficult to formulate or manufacture
  • Possibility of discovering new patentable solid forms

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