Discover

Discover

Thanks to an expert and dedicated team with a solid state chemistry background, PolyCrystalLine is proud to support their clients in the identification of the proper solid form with the required biopharmaceutical properties through polymorph/salt/co-crystal screening to push forward the API into the next development.

Preformulation Studies

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Amorphous Dispersion

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Co-crystals Screening

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Polymorph Screening

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Salts Screening

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Solid Form Selection

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Analize

Analize

At PolyCrystalLine we offer a complete range of analytical capabilities to support your requirements. Our highly qualified scientist operate in top class laboratories fully furnished with state of the art equipment. Our laboratories have been inspected by FDA, are GMP certified by AIFA and are authorized to the handling and the study of HPAPIs up to OEB5.

cGMP Analyses

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Thermal Analysis

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Structural Characterization

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Paticle Characterization

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Physicochemical analyses

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Dynamic Vapor Sorption (DVS)

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Design & develop

Design & develop

Every stage of an API production can affect the final product increasing the cost and risks. In PolyCrystalLine, we optimize the processes ranging from synthetic route scouting to process scale-up. Ensuring with the use of automatic reactors the monitoring of all the parameters than will affect the development of flexible and robust procedure that can be transferred to our kilo-scale plant.

Process Optimization

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Process Development

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Process Impurities

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Route Scouting

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Manufacture

Manufacture

The integration of our CRO knowledge and CDMO capabilities places PolyCrystalLine as an excellent partner in the production of intermediates and APIs in GMP compliance. Our team can support you in the optimization and in the synthesis of challenging molecules from gram to kilogram scale with consistency and optimized physical and bulk properties.

Scale-Up and Tech Transfer

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Custom Synthesis

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