The amorphous form does not possess a defined order in its arrangement. Although the amorphous form is the most soluble form, it exhibits the lowest stability. Amorphous compounds are produced in the conditions when precipitation is kinetically faster than crystallisation and crystalline disorder caused by processing (i.e. milling or micronisation).
It is also possible that more than one distinct amorphous phase may be formed from the same substance. In analogy with the phenomenon of crystalline polymorphism, this behaviour has been termed “amorphous polymorphism”.
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- Amorphous materials can significantly increase bioavailability of poorly-water soluble drugs
- Understanding the crystallization of amorphous material is crucial for process development