PolyCrystalLine was founded in 2005 as a business idea developed in an academic context. The company was born out of the Molecular Crystalline Engineering (MCE) group of research coordinated by Professor Dario Braga in the Department of Chemistry “G. Ciamician” of the University of Bologna.
The MCE group has been working for many years in the field of crystal polymorphism and is one of the most specialized in Italy. In decades of collaboration with the pharmaceutical industry, the MCE group has developed its own techniques to induce and check the formation of polymorphic or solvate (generally hydrated) crystal forms.
In 2007 PolyCrystalLine moved its activities out of the Department of Chemistry, transferring its university know-how into a dedicated site in the suburbs of Bologna.
In September 2009 PCL moved premises into larger custom-built laboratories and offices in Medicina.