SUNDAY 10 September
Aula Magna Chemistry Department G. Ciamician
11:30-14:00
REGISTRATION
14:00-14:30
Dario Braga
Department of Chemistry G. Ciamician, University of Bologna, Italy
Opening of the convention
14:30-15:00
Aurora J Cruz-Cabeza
Department of Chemistry, Durham University, Durham, UK
Crystal size and shape effects in polymorphism
16:00-16:30
Lucia Maini
Department of Chemistry G. Ciamician, University of Bologna, Italy
Failure and success in the crystal engineering lab
15:30-16:00
Edyta Pindelska
Department of Pharmaceutical Chemistry and Biomaterials, Medical University of Warsaw, Warsaw, Poland
To taste and not to forget. Can crystal engineering solve a problem of Alzheimer’s disease?
15:00-15:30
Ashwini K. Nangia
Senior Professor of Chemistry, University of Hyderabad, INDIA
Improving solubility and permeability of drugs by cocrystallization
16:30-17:00
COFFEE BREAK
17:00-17:30
Amy Woods-Ryan
Investigator Materials Science, Drug Substance Development – GSK Medicines Research Centre, Stevenage, Hertfordshire, UK
A to Z of Polymorphs Related by Proton Transfer
17:30-18:00
Helen Wheatcroft
APS Crystallisation Scientist, AstraZeneca, Macclesfield, UK
Crystallisation and Particle Control of a Multi-component API Crystal Form: From Structure to Process
18:30-19:00
Susan Bourne
Department of Chemistry, The University of Cape Town, South Africa
Modifying properties of solid forms by supramolecular interactions
18:00-18:30
Tomislav Friscic
Professor & Leverhulme International Chair in Green and Sustainable Chemistry School of Chemistry – University of Birmingham
Speed-Mixing and Resonant Acoustic Mixing: New Opportunities for Discovery and Scale-up of Polymorphs and Cocrystals
19:00
DINNER IN THE COURTYARD
MONDAY 11 September
Hotel Aemilia
8:30-9:00
Jon Steed
Department of Chemistry, Durham University, Durham, UK
Supramolecular Gels – morphology/property relationship and polymorph discovery.
9:00-9:30
Helen Blade
AstraZeneca UK 1 Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, CB2 0AA.
From Crystal Structures to Patients – How AZ uses crystal structure models to risk assess our molecules
9:30-10:00
Robert Geertman
Crystallization Technology Unit Janssen R&D BE API Development, Beerse, Belgium
Navigating a solvate jungle
10:00-10:30
Ana Kwokal
Team Lead, Particle Science at Syngenta, UK
Solid-solution challenges
10:30-11:00
COFFEE BREAK
11:00-11:30
Doris Braun
University of Innsbruck Institute of Pharmacy, Innsbruck, Austria
Experimental and theoretical studies of flavone cocrystals
11:30-12:00
Andrea Anelli
Digitalisation and Data Scientist, Roche Pharma Research and Early Development Roche Innovation Center Basel, Switzerland
Accelerating crystal structure prediction using machine learning
12:00-12:30
Sarah (Sally) Price
Department of Chemistry, University College London, UK
Are we making progress towards polymorph prediction?
12:30-13:00
Marcus A. Neumann
CEO Avant-garde Materials Simulation Deutschland GmbH, Merzhausen, Germany
Crystal Structure Prediction for Ocean Planets 2.0
13:00-14:00
LUNCH
14:00-14:30
Enrico Modena
PolyCrystalLine spa – Medicina, Bologna, Italy
Polymorphism of APIs and crystallization control
14:30-15:00
Javier Alcides Ellena
São Carlos Institute of Physics – University of São Paulo, Brasil
Antihypertensives Drug-Drug co-crystals: drug combination for the treatment of covid sequels
15:00-15:30
Paroma Chakravarty
Sr. Principal Scientist, Small Molecule Pharmaceutical Sciences Genentech, Inc. South San Francisco, USA
The Importance of Solid-state Chemistry in Advancing the Small Molecule Drug Development Pipeline
15:30-16:00
Gerard Coquerel
Laboratoire Sciences et Méthodes Séparatives. University of Rouen, France
Access to highly metastable polymorphs after smooth desolvations. Conditions to fulfill and examples.
16:00-16:30
COFFEE BREAK
16:30-16:45
Gold sponsor presentation
Anton Paar Italia S.r.l.
16:45-17:00
Gold sponsor presentation
Dompè
17:00-18:00
discussants
Ghazala Sadiq
The Cambridge Crystallographic Data Centre, Cambridge, UK
Susan Reutzel Edens
The Glass Ceiling – Open discussion *
18:00-20:00
POSTER SESSION AND APERITIF
TUESDAY 12 September
Hotel Aemilia
8:30-8:45
Gold sponsor presentation
SMS/Nordtest
8:45-9:00
Gold sponsor presentation
Mettler-Toledo S.p.A.
9:00-9:30
Mike Zaworotko
Bernal Chair of Crystal Engineering, Department of Chemical Sciences, AD2-021 University of Limerick Limerick, Ireland
Nutraceutical cocrystals
9:30-10:00
Matteo Daldosso
Material Science Scientific Leader, Aptuit, an Evotec Company, Verona, Italy
The influence of particle attributes on inhalation drug products performance: few non-trivial cases
10:00-10:30
Lidia Tajber
School of Pharmacy and Pharmaceutical Sciences Trinity College Dublin, Dublin, Ireland
To crystallize or not to crystallize – that is the question, but what is better for making good medicines?”
10:30-11:00
COFFEE BREAK
11:00-11:30
Elena Simone
Department of Applied Science and Technology (DISAT) Politecnico di Torino, Torino, Italy
Relating crystal structure to particle surface properties: bringing crystal engineering with particle technology
11:30-12:00
Nicola Sardone
Analytical Research Director INDENA, Settala (Mi), Italy
Industrial case studies of solid form behaviour in drugs substances and drug products
12:00-12:30
Pat Basford
Senior Principal Scientist, Pfizer
The enigma of hydrate kinetic stability, yet a necessity for drug product development
12:30-13:00
Gianluca Bianchini
Medicinal Chemistry Associate Director – Dompé farmaceutici S.p.A, L’Aquila, Italy
Ketoprofen, lysine and gabapentine co-crystal magnifies synergistic efficacy and tolerability of the constituent drugs: pre-clinical evidences towards innovative therapeutic approach for neouroinflammatory pain
13:00-14:00
LUNCH
14:00-14:30
Oleksii Shemchuk
Université Catholique de Louvain – UCLouvain, Louvain-la-Neuve, Belgium
Innovative pathways to chiral resolution using cocrystallization tools
15:30-16:00
C. Malla Reddy
Department of Chemical Sciences, IISER Kolkata, India
Nanomechanics of Crystal Forms
15:00-15:30
Bucar Kreso
Department of Chemistry, University College London, London, UK
Crystal engineering of palatable medicines: what works and what doesn’t
14:30-15:00
Varvara (Varia) Nikolayenko
Laboratory Head: Early Solid-State at Bayer AG, Wuppertal, North Rhine-Westphalia, Germany
Strategically navigating the complex and varied solid-state landscape of API’s
16:00-16:30
COFFEE BREAK
17:30-18:30
Dario Braga and Susan Reutzel Edens (discussants)
What next in crystal forms? Open discussion
16:30-17:00
Matteo Guidetti
Solvias AG Römerpark 2 CH-4303 Kaiseraugst, Switzerland
Combining high-throughput experiments and computational tools in the cocrystal screening of posaconazole
17:00-17:30
Alfred Lee, Ph.
Merck Research Laboratories Rahway, New Jersey 07065, USA
Solid Form Science in Chemical Process Development: The Good, The Bad and The Ugly
18:30-19:00
CLOSING REMARKS AND POSTER PRIZES
*open discussion led by Ghazala Sadiq and Susan Reutzel Edens (discussants) to address “under the iceberg’ moments” people have experienced, the challenges people face, mentorship and the small changes that may make a difference.
-> The issue of “sustainability of conferences and meetings” will also be addressed via a questionnaire and a poster discussion.
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